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Safety Information
Treatment: Personalized Semaglutide+
Last Updated: September 1, 2025

Important Safety Information Regarding Compounded Semaglutide

Compounded Medication Disclaimer

Compounded medications, including semaglutide, are not approved by the U.S. Food and Drug Administration (FDA) and do not undergo the same clinical studies as FDA-approved drugs to evaluate safety or efficacy. Compounded medications may still be legally prescribed when determined appropriate by a licensed healthcare provider following a medical consultation.

Eligibility

You may qualify for treatment if:

  • Your Body Mass Index (BMI) is 30 or higher, or
  • Your BMI is 27 or higher with at least one weight-related condition such as high blood pressure, type 2 diabetes, or high cholesterol.

If your BMI is above 25, you may still be at risk for health issues and could qualify depending on your overall medical history. Eligibility is determined on a case-by-case basis. A licensed healthcare provider will carefully review your intake to confirm eligibility and ensure treatment is safe and appropriate for you.

Indication

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for chronic weight management in combination with a reduced-calorie diet and increased physical activity.

Contraindications

Do not use semaglutide if:

  • You or a family member has a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  • You have had a severe allergic reaction to semaglutide or any of its ingredients in the past.

Warnings and Precautions

Serious side effects may occur with semaglutide use, including:

  • Thyroid Tumors: Risk of thyroid cancer. Report neck lumps, hoarseness, difficulty swallowing, or shortness of breath to your provider immediately.
  • Gastroparesis (Stomach Paralysis): Symptoms include early satiety, nausea, vomiting, or prolonged stomach discomfort.
  • Pancreatitis: Severe abdominal pain, with or without vomiting, may indicate pancreatitis.
  • Gallbladder Disease: Symptoms may include abdominal pain, jaundice, or clay-colored stools.
  • Hypoglycemia: Low blood sugar, especially when used with insulin or sulfonylureas. Symptoms may include shakiness, sweating, confusion, or blurred vision.
  • Kidney Impairment: Dehydration caused by nausea or diarrhea may worsen kidney function.
  • Severe Allergic Reactions: Seek immediate care if you experience swelling of the face or throat, difficulty breathing, rash, or rapid heartbeat.
  • Mental Health Changes: New or worsening depression, mood changes, or suicidal thoughts must be reported to your provider immediately.

Precautions Before Use

Inform your healthcare provider if you:

  • Have or have had pancreas or kidney problems.
  • Have type 2 diabetes and a history of diabetic retinopathy.
  • Are pregnant, planning to become pregnant, or breastfeeding. Semaglutide is not recommended during pregnancy or breastfeeding.
  • Are taking other medications, including prescriptions, over-the-counter drugs, vitamins, or supplements.

Administration

  • Semaglutide is administered once weekly by subcutaneous injection in the stomach, thigh, or upper arm.
  • Follow dosing instructions provided by your healthcare provider.
  • Do not adjust or discontinue semaglutide without consulting your provider.

Mechanism of Action

Semaglutide is a synthetic GLP-1 receptor agonist that helps regulate blood sugar and appetite. It stimulates insulin secretion, inhibits glucagon release, and supports appetite control.

Common Side Effects

The most common side effects include:

  • Gastrointestinal symptoms such as nausea, diarrhea, constipation, and abdominal pain.
  • Headache, fatigue, dizziness, and mild hypoglycemia (in patients with type 2 diabetes).

This list does not include all possible side effects. Consult your healthcare provider regarding any adverse effects you may experience.

Important Notes

  • Semaglutide treatment should only be initiated and monitored by a licensed healthcare provider.
  • If you experience a medical emergency, call 911 immediately.
  • For additional safety information, contact FDA MedWatch at 1-800-FDA-1088 or visit www.fda.gov/medwatch.

Commitment to Safety

Yucca Health is committed to providing safe, transparent, and high-quality care. We encourage patients to discuss all concerns openly with their provider to ensure the best possible treatment outcomes.