GLP-1 (Semaglutide)

GLP-1 is a hormone your body releases after you eat. It signals fullness to your brain and slows how quickly food leaves your stomach — but it clears from your system within minutes.

GLP-1 medications are built to do the same job and stay active far longer, so the fullness signal holds instead of fading between meals. They’re prescribed as once-weekly injections you give yourself at home.

See how semaglutide works See how tirzepatide works

The largest published weight-management trial of branded semaglutide studied 1,961 adults over 68 weeks at a 2.4 mg weekly dose. Average weight change was −14.9%, compared with −2.4% on placebo.

A separate cardiovascular outcomes trial studied branded semaglutide 2.4 mg in adults aged 45 and older with established cardiovascular disease and overweight or obesity, without diabetes. Major cardiovascular events occurred in 6.5% of the semaglutide group versus 8.0% on placebo.

Both studied FDA-approved finished drugs, not compounded preparations. They don’t establish outcomes for compounded semaglutide, and they don’t predict your individual result.

See semaglutide plans

As a once-weekly subcutaneous injection, starting low and increasing gradually so your body adjusts. A standard schedule holds each dose level for at least four weeks before stepping up.

Your clinician sets your schedule and may keep you at a level longer based on how you respond. Many patients stay below the maximum dose, and that’s a normal outcome rather than a shortfall.

See the full dosing schedule Start your intake

We don’t know, and anyone who tells you a number for your specific case is guessing. Individual response varies with dose, how consistently you take the medication, diet, activity, and individual biology.

What we can tell you is what the published research on the branded, FDA-approved medications shows:

• In a 68-week trial of branded semaglutide 2.4 mg in 1,961 adults, average weight change was −14.9%, compared with −2.4% on placebo.
• In a 72-week trial of branded tirzepatide in 2,539 adults, average weight reductions were −15.0%, −19.5% and −20.9% at the 5 mg, 10 mg and 15 mg doses, compared with −3.1% on placebo.

Those trials studied FDA-approved finished drugs, not compounded preparations, and they don’t predict your individual result. Your clinician can talk through what’s realistic for you.

If you complete six continuous months of GLP-1 injectable treatment as prescribed and haven’t lost weight compared with your logged starting weight, we refund everything you paid us over those six months — medication, consultation fees, and plan fees. There’s nothing to send back.

It’s our commitment that six months of treatment shouldn’t cost you anything if it doesn’t work for you.

It is not a medical guarantee. We’re not promising you’ll lose weight, and individual results vary. Your clinician’s guidance always comes first.

It applies to GLP-1 injectable plans started on or after September 18, 2026.

Read the full terms

No. The medications prescribed through Yucca Health are compounded preparations, and compounded medications are not FDA-approved. The FDA does not review compounded drugs for safety, effectiveness, or manufacturing quality before they’re marketed.

A compounded preparation is made by a licensed pharmacy for an individual patient, pursuant to a prescription from a clinician who has determined a compounded preparation is appropriate for that patient.

A compounded preparation is not the same as, and is not a substitute for, any FDA-approved product. We make no claim that it is equivalent in safety, effectiveness, or quality.

Talk to your clinician about the risks, benefits, and alternatives — including FDA-approved options — before starting.

Read full safety information

For GLP-1 weight management medications, the most common are gastrointestinal: nausea, diarrhea, constipation, vomiting, and abdominal discomfort. These are most common early and while your dose is increasing.

Headache, fatigue, and dizziness can also occur.

This isn’t a complete list. Tell your clinician about anything persistent or concerning — there’s usually something that can be adjusted.

Read full safety information